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KMID : 0665220140270061090
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Korean Journal of Food and Nutrition
2014 Volume.27 No. 6 p.1090 ~ p.1095
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Antioxidant Activity and Protective Effects of Anthocyanins-Rich Fraction from Korean Purple Sweet Potato Variety, "Shinjami" against Oxidative Stress in HepG2 Cell
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Jang Hwan-Hee
Nam Song-Yee
Kim Mi-Ju
Kim Jung-Bong
Kim Haeng-Ran
Lee Young-Min
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Abstract
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Anthocyanins, a class of flavonoids, are natural water-soluble pigments, which are mainly found in vegetables and fruits. Anthocyanins have attractive pharmacological activities, such as anti-oxidant, anti-inflammatory, anti-cancer, and anti-diabetic. The purpose of this study was to investigate the protective effects of anthocyanins-rich fraction (ANF) from Korean purple sweet potato variety, "Shinjami", against hydrogen peroxide (H2O2)-induced oxidative stress. In our results, pre-treatment of HepG2 cells with ANF (10μg/mL) significantly prevented cell death and maintained cell integrity, following exposure to 0.9 mM hydrogen peroxide. The H2O2-dependent production of intracellular ROS was also significantly decreased by pre-treatment with ANF (6 h, 10μg/mL). In addition, ANF increased the mRNA levels of antioxidant enzymes, catalase and glutathione level in H2O2-treated HepG2 cells. These results indicated that ANF protected HepG2 cells against H2O2-induced oxidative stress by inducing protective system.
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KEYWORD
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anthocyanin, flavonoid, purple sweet potato, anti-oxidant, hydrogen peroxide
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